Mary Ann Santos Pefanco, M.D.

Internal Medicine

Mary Ann Santos Pefanco is an Internal Medicine specialist based in Hilo, HI with over 27 years of clinical experience. Medicare-enrolled per CMS records and offers virtual telehealth visits.

Also practices: INTERNAL MEDICINE

Telehealth Available
NPI Active per CMS — Q2 2026|Medicare Enrolled|Order & Refer

With over 27 years in internal medicine, Mary Ann Santos Pefanco, M.D. is a long-established internist in Hilo. With 27+ years of experience, she has been practicing in the Hilo area. CMS Medicare data shows her patients commonly have hypertension, high cholesterol, and arthritis. CMS MIPS quality score: 83.95/100 (2023).

At a glance

  • Prescribes opioids less than 29% of reporting doctors in Hawaii
  • Uses generic medications more than 73% of reporting doctors in Hawaii
  • Federal MIPS score higher than 27% of MIPS-scored doctors in Hawaii
  • Virtual visits available — no app or travel required
1 of 175 Internal Medicine providers in HISee all Internal Medicine in Hilo27+ years experienceNPI since 2006

Older · 6638dNPPES updated 2008-03-20 · verify NPI on CMS · Verify license at Hawaii Medical Board

Contact & Location

Practice Location

1178b Kinoole St, Hilo, HI 96720-4133

Fax: (808) 961-4909
CMS Clinical Data

How Does This Doctor Compare?

Based on Medicare data, this doctor prescribes opioid pain medications conservatively, favors affordable generic drugs over brand-name ones.

MIPS Score

2023

83.95/100

Hawaii avg: 83.7 · US avg: 83.6

Higher than most doctors nationally(+0.4 pts)

How the government rates this doctor's Medicare care quality. Scores above 75 are considered good.

Opioid Rx

↓ Lower = better

2.67%

Hawaii avg: 5.3 · US avg: 5.1

Higher than most doctors nationally(-2.4 pts)

2.67% of this doctor's prescriptions are opioid pain medications. Lower means more cautious prescribing.

Generic Rx

↑ Higher = better

89.8%

Hawaii avg: 81.8 · US avg: 82.8

Higher than most doctors nationally(+7 pts)

Better than 73% of reporting doctors in Hawaii

How often this doctor prescribes affordable generic drugs instead of expensive brand-name ones.

Medicare Patients

389

Unique beneficiaries

Standard volume

Prescription Recipients

513

Patients prescribed

Prescriptions Written

7,827

Total claims

Total Medicare drug cost: $547k

Percentile rankings compared against 262 reporting peers in Hawaii.

Data Note: Sourced from CMS Medicare Provider Utilization & Payment Data. Percentile rankings compare this provider against all peers with reported data in the same state. Updated annually to reflect the latest federal reporting cycle.

Patient Condition Panel

What This Doctor Treats Most

Based on Medicare claims data — here's what patients commonly see this doctor for

Based on Medicare data, this doctor primarily manages Hypertension, High Cholesterol, and Arthritis.

Hypertension
Higher than avg (+5%)75%

High blood pressure — a leading risk factor for heart disease and stroke

US avg: 70.2%

↑ More patients than average (+5%) — a focus area for this doctor

High Cholesterol
Higher than avg (+2%)72%

Elevated cholesterol or triglycerides that increase heart disease risk

US avg: 70.4%

↑ More patients than average (+2%) — a focus area for this doctor

Arthritis
Lower than avg (-2%)47%

Joint inflammation causing pain, swelling, and stiffness

US avg: 49.3%

↓ Fewer patients than average (-2%) — less common here

Osteoporosis
Higher than avg (+21%)39%

Weakened bones that are more prone to fractures, common in older adults

US avg: 18.1%

↑ More patients than average (+21%) — a focus area for this doctor

Anxiety Disorders
Higher than avg (+1%)35%

Excessive worry or fear that interferes with daily life

US avg: 34.1%

↑ More patients than average (+1%) — a focus area for this doctor

Mood Disorders
34%

Conditions affecting emotional state, including depression and bipolar disorder

Depression
32%

A mood disorder causing persistent sadness and loss of interest in activities

US avg: 31.8%
Chronic Kidney Disease
Higher than avg (+1%)31%

Gradual loss of kidney function over time, often linked to diabetes or hypertension

US avg: 29.6%

↑ More patients than average (+1%) — a focus area for this doctor

GeneralBehavioralNational avg

Percentage of this provider's Medicare patients diagnosed with each condition. Source: CMS Utilization Data.

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Background & Specialty

Education, training, and specialty classification from CMS NPPES and Medicare records.

Career Journey
  1. 27 years in practice

    Experienced

Internal MedicineAllopathic & Osteopathic Physicians

A physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults and the elderly. Internists are trained in the diagnosis and treatment of cancer, infections and diseases affecting the heart, blood, kidneys, joints and digestive, respiratory and vascular systems. They are also trained in the essentials of primary care internal medicine, which incorporates an understanding of disease prevention, wellness, substance abuse, mental health and effective treatment of common problems of the eyes, ears, skin, nervous system and reproductive organs.

Taxonomy: 207R00000X

Practice Footprint

Mailing address

224 Haili St Ste B, Hilo, HI 96720-2975

Differs from practice location

Virtual Internal Medicine Care With Mary Ann Santos Pefanco

NPPES records indicate this provider offers telehealth services. Contact the office to confirm availability and scheduling.

Schedule a virtual visit with Mary Ann Santos Pefanco for blood pressure monitoring, cholesterol management, arthritis follow-ups — no travel to Hilo required. The office sends a secure video link before your appointment. Most visits take 15–30 minutes. Medicare enrolled per CMS records.

Frequently Asked Questions

Common questions about Mary Ann Santos Pefanco

Dr. Pefanco is listed as active in the NPI registry with telehealth listed in Hilo, HI. NPI status alone doesn't confirm open availability — call the office to confirm. Phone: (808) 969-1427.

Verified across 5 federal data sources

Sourced from CMS NPPES · OIG LEIE · CMS QPP 2023 · CMS Medicare Part D · CMS Physician Comparator. See Data Methodology.

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Medical Disclaimer: NPI Telehealth is a provider directory for informational purposes only. This page does not constitute medical advice, diagnosis, or treatment recommendations. Provider data is sourced from the CMS NPPES federal registry and public Medicare datasets. NPI Telehealth does not verify clinical qualifications beyond federal records. Data may not reflect real-time availability — always contact the provider's office directly to confirm details before seeking care.

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