Mary Denise Hughes, MD
Neurology Psychiatry & Neurology
Mary Denise Hughes is a Neurology Psychiatry & Neurology specialist based in Greenville, SC with over 37 years of clinical experience. Medicare-enrolled per CMS records and offers virtual telehealth visits.
Mary Denise Hughes, MD has practiced psychiatry & neurology for 37+ years, working in group practice. Trained at University of Tennessee, Hsc, College of Medicine (class of 1989), she has been practicing for over 37 years. CMS Medicare data shows her patients commonly have high cholesterol, hypertension, and mood disorders.
Older · 509dNPPES updated 2024-12-30 · verify NPI on CMS · Verify license at South Carolina Board of Medical Examiners
Contact & Location
Practice Location
52 Bear Dr, Greenville, SC 29605-4458
How Does This Doctor Compare?
Generic Rx
↑ Higher = better79.6%
South Carolina avg: 83.3 · US avg: 82.8
⚠ Lower than most doctors nationally(-3.2 pts)
How often this doctor prescribes affordable generic drugs instead of expensive brand-name ones.
Medicare Patients
106
Unique beneficiaries
Standard volumePrescription Recipients
114
Patients prescribed
Prescriptions Written
485
Total claims
Total Medicare drug cost: $211k
Percentile rankings compared against 605 reporting peers in South Carolina.
Data Note: Sourced from CMS Medicare Provider Utilization & Payment Data. Percentile rankings compare this provider against all peers with reported data in the same state. Updated annually to reflect the latest federal reporting cycle.
What This Doctor Treats Most
Based on Medicare claims data — here's what patients commonly see this doctor for
Based on Medicare data, this doctor primarily manages High Cholesterol, Hypertension, and Mood Disorders.
Elevated cholesterol or triglycerides that increase heart disease risk
US avg: 70.4%↑ More patients than average (+5%) — a focus area for this doctor
High blood pressure — a leading risk factor for heart disease and stroke
US avg: 70.2%↓ Fewer patients than average (-4%) — less common here
Conditions affecting emotional state, including depression and bipolar disorder
Joint inflammation causing pain, swelling, and stiffness
US avg: 49.3%↓ Fewer patients than average (-2%) — less common here
A mood disorder causing persistent sadness and loss of interest in activities
US avg: 31.8%↑ More patients than average (+15%) — a focus area for this doctor
Excessive worry or fear that interferes with daily life
US avg: 34.1%↑ More patients than average (+4%) — a focus area for this doctor
Reduced blood flow to the heart muscle, commonly known as coronary artery disease
US avg: 31.7%↓ Fewer patients than average (-8%) — less common here
A condition where the body cannot properly regulate blood sugar levels
US avg: 34.5%↓ Fewer patients than average (-11%) — less common here
Percentage of this provider's Medicare patients diagnosed with each condition. Source: CMS Utilization Data.
$48.8k received from industry
153 transactions reported in 2024 ·Very High tier
Payments include consulting fees, speaking honoraria, food & beverage, travel, research support, and ownership interests from drug and medical device manufacturers. Disclosure is required by the federal Physician Payments Sunshine Act. These payments do not necessarily indicate conflicts of interest. National median: $338 across 136 000 tracked providers.
Tiers — Low: under $500 · Moderate: $500-5 000 · High: $5 000-25 000 · Very High: $25 000+. Source: CMS Open Payments 2024, attributed to Mary Denise Hughes's NPI.
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Background & Specialty
Education, training, and specialty classification from CMS NPPES and Medicare records.
Graduated medical school · 1989
University of Tennessee Health Science Center
Board certified · Dec 29, 2024
Self-reported via NPPES
37 years in practice
Senior practitioner
Neurologists diagnose and treat disorders of the nervous system including stroke, epilepsy, multiple sclerosis, Parkinson's disease, migraines, neuropathy, and dementia.
Taxonomy: 2084N0400X
Education & Training
University of Tennessee, Hsc, College of Medicine (Class of 1989)
Mailing address
Po Box 24217, Greenville, SC 29616-4217
Differs from practice location
Virtual Psychiatry & Neurology Care With Mary Denise Hughes
NPPES records indicate this provider offers telehealth services. Contact the office to confirm availability and scheduling.
Schedule a virtual visit with Mary Denise Hughes for cholesterol management, blood pressure monitoring, mood disorder follow-ups — no travel to Greenville required. The office sends a secure video link before your appointment. Most visits take 15–30 minutes. Medicare enrolled per CMS records.
Frequently Asked Questions
Common questions about Mary Denise Hughes
Dr. Hughes is listed as active in the NPI registry with telehealth listed in Greenville, SC. NPI status alone doesn't confirm open availability — call the office to confirm. Phone: (864) 655-4005.
Sourced from CMS NPPES · OIG LEIE · CMS Medicare Part D · CMS Open Payments 2024 · CMS Physician Comparator. See Data Methodology.
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Contact Mary Denise Hughes
Practice Location
52 Bear Dr, Greenville, SC 29605-4458
Mailing Address
Po Box 24217, Greenville, SC 29616-4217
This is a provider directory. Contact the office directly to schedule appointments.
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